The Jambos, who won their first title on the final day of the season, are now managed by Andy Thompson following Eva Olid's departure after five years in charge.
Rangers, who finished two points behind the Jambos, start away to Montrose as Leanne Crichton looks to win her first silverware as head coach.
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After finishing a disappointing fifth last season, Celtic face a tough opening day trip to 16-time winners Glasgow City.
The Petershill Park side remained in contention for much of last season, but eventually finished in third.
Hibernian ended their title defence season in fourth and will look to bounce back, starting with a home game against Motherwell.
Newly-promoted Spartans will begin life in the top-flight against Partick Thistle, who have Gary Holt in charge after kicking off last summer under David Elliot.
The first SWPL Old Firm clash is scheduled for September 27 when Rangers welcome Celtic to Broadwood Stadium.
What about SWPL 2?
In the ScottishPower Women's Premier League 2, last season's runners-up Kilmarnock are away to Renfrew on the opening day after their promotion from the Scottish Women's Championship.
Falkirk are also in the SWPL 2 following their win over East Fife in the play-off final and start the new campaign away to Dundee United.
Elsewhere, St Johnstone host Livingston, Hamilton are at Queen's Park and Gartcairn take on Boroughmuir Thistle.
