Most Valuable Promotions (MVP) have confirmed that Mayer vs Cameron will headline MVPW-06 at the bp pulse LIVE arena in Birmingham on August 29, where every fight on the main card will see a UK vs USA contest.
The UK's WBO super welterweight world champion Cameron (22-1, 8 KOs) faces the USA's unified WBA and WBC super welterweight world champion Mayer (22-2, 5 KOs), with all three world titles on up for grabs in the 10-round contest.
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Cameron won the WBO super welterweight title with a dominant performance over Michaela Kotaskova in April, a belt Mayer had won then vacated just months prior, and Mayer now looks to reclaim it alongside her WBA and WBC hardware.
"I am over the moon this fight has been made," Cameron said. "I've always said I want the biggest fights in women's boxing, and there isn't a bigger fight right now than me against Mikaela Mayer."
The intriguing battle between two world champions will be both fighters' first defences at 154lbs and contested over 10 two-minute rounds, while the main card will be composed entirely of female fighters.
Mayer added: "Cameron has always been a name I've hoped to add to my resume and a fight I feel the sport of boxing deserves. With our come forward, aggressive styles, I have no doubt that it will be one of the most exciting fights of our generation."
The co-main event will see the UK's unified WBC and WBO lightweight world champion Caroline Dubois face a 10-round unified championship defence against American Amelia Moore, contested at 135lbs with two-minute rounds.
"I'm excited to be fighting in the UK at home again," Dubois said. "The crowd in London last time was incredible. I am looking forward to representing the UK on this card and defending my unified titles.
"The goal is to fight for more belts at the end of the year so I need to focus and take care of business with a big win in Birmingham."
Since inception in 2021, MVP has produced over 30 live boxing events and currently promotes over 60 fighters, 15 world champions, and 26 top contenders. Tickets for MVPW-06 UK vs USA go on sale June 19 at 10am BST via AXS.com.
"MVPW-06 UK vs USA delivers one of the most important fights that can be made in women's boxing today," said Jake Paul and Nakisa Bidarian, co-founders of Most Valuable Promotions.
"Since the [Katie] Taylor vs [Amanda] Serrano trilogy, there has not been a pound-for-pound match-up of this magnitude, with two of the world's top six fighters meeting in their prime.
"Mikaela Mayer and Chantelle Cameron are proven champions who have consistently sought out the toughest challenges available, and this fight is no different.
"Coming on the heels of MVPW-05: Johnson vs Thorslund on Saturday August 8, MVP is putting together a remarkable month for women's boxing and continuing to deliver the elite match-ups fans deserve."
Third time lucky for Mayer in England?
Mayer's only two previous professional defeats have come on UK soil, with a controversial split-decision loss to Alycia Baumgardner in London in 2022 and a split-decision loss to Natasha Jonas in Liverpool in January 2024.
A Jonas rematch did not happen but Mayer seized her second opportunity to become a two-weight world champion later that year, defeating WBO welterweight world champion Sandy Ryan in a Fight of the Year contender.
Mayer beat Ryan in the rematch before conquering a third weight class in her last fight in October, dominating Canadian star Mary Spencer over 10 rounds in Montreal to capture the WBA, WBC and WBO junior middleweight titles.
"I know I haven't had always the best luck over there in the UK, but I've always said that hasn't deterred me from coming back there," Mayer exclusively told Sky Sports.
"I love fighting over there, I love the fans over there, the people, the energy in the arena - it's always great. I'm just going to have to go and get it done this time. Three's a charm!"
Watch MVPW-06 in Birmingham, headlined by Mikaela Mayer v Chantelle Cameron and with Caroline Dubois also in action, live on August 29 on Sky Sports. Get Sky Sports or stream boxing with no contract.
