Diabetic drug metformin found to act on brain

A study published in Science Advances by Baylor College of Medicine has uncovered a hidden brain pathway that helps explain how metformin lowers blood sugar, offering fresh insight into a medicine used for over six decades. For years, metformin was believed to act mainly on the liver and gut. The new research shows it also works through the ventromedial hypothalamus — a small but crucial brain region that controls hunger, energy use and glucose balance.